Searchable abstracts of presentations at key conferences in endocrinology

ea0081rc4.3 | Rapid Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

Pre-treatment GH levels and number of therapeutic interventions for acromegaly management are predictive of altered MRI bone shape and severity of arthropathy in acromegaly

Kyriakakis Nikolaos , Bowes Michael , Lynch Julie , Kingsbury Sarah R , M Orme Steve , Murray Robert D , Conaghan Philip G

Introduction: Emerging research in 3D-bone shape has provided new insights into the pathogenesis of osteoarthritis (OA). OA patients have increased subchondral bone area, associated with higher prevalence of cartilage loss. Higher B-score, a novel, machine learning-derived OA bone biomarker, is associated with increased OA symptom severity and structural progression. Arthropathy, despite being the commonest cause of morbidity amongst acromegaly patients, remains one of the und...